The story of Claire Randall, a married combat nurse from 1945 who is mysteriously swept back in time to 1743, where she is immediately thrown into an unknown world where her life is threatened. When she is forced to marry Jamie, a chivalrous and romantic young Scottish warrior, a passionate affair is ignited that tears Claire's heart between two vastly different men in two irreconcilable lives.
Jamie's authority is tested when an old rival from Ardsmuir shows up to settle on the Ridge. Claire finds a new way to cope with the trauma of her assault by Lionel Brown.
Jamie struggles with his first request as Indian Agent. Roger presides over an unusual funeral. Marsali gives birth. However, the joy is short lived when a discovery is made.
Fergus worries about his new son's quality of life when the baby is bullied by superstitious Protestants. Claire performs surgery on Tom's hand.
While visiting the Cherokee, Ian encounters a man from his past who dredges up painful memories of his time with the Mohawk. Jamie meets an Indian Agent who challenges his convictions, causing him to re-evaluate.
Claire and Jamie experience the rising tensions in the colonies first-hand when they attend a Loyalist event in Wilmington in honor of the Scottish heroine, Flora MacDonald.
A dysentery epidemic spreads on the Ridge, and Claire falls deathly ill. She is almost recovered when the Christies arrive and drop a bombshell. As nefarious rumors spread like wildfire on the Ridge, tragedy strikes.
Claire struggles with her demons as a nefarious rumor begins to spread on the Ridge. Tensions rise as the residents fear there is a dangerous person in their midst.
Richard Brown and his Committee of Safety arrive to arrest Claire for murder. However, due to the rising political tensions in the colonies, Brown's plan to find a judge for a trial does not go as expected.